Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease
- Meurs, J.B.J. van
- Pare, G.
- Schwartz, S.M.
- Hazra, A.
- Tanaka, T.
- Vermeulen, S.
- Cotlarciuc, I.
- Yuan, X.
- Malarstig, A.
- Bandinelli, S.
- Bis, J.C.
- Blom, H.
- Brown, M.J.
- Chen, C.
- Chen, Y.D.
- Clarke, R.J.
- Dehghan, A.
- Erdmann, J.
- Ferrucci, L.
- Hamsten, A.
- Hofman, A.
- Hunter, D.J.
- Goel, A.
- Johnson, A.D.
- Kathiresan, S.
- Kampman, E.
- Kiel, D.P.
- Kiemeney, L.A.L.M.
- Chambers, J.C.
- Kraft, P.
- Lindemans, J.
- McKnight, B.
- Nelson, C.P.
- O'Donnell, C.J.
- Psaty, B.M.
- Ridker, P.M.
- Rivadeneira, F.
- Rose, L.M.
- Seedorf, U.
- Siscovick, D.S.
- Schunkert, H.
- Selhub, J.
- Ueland, P.M.
- Vollenweider, P.
- Waeber, G.
- Waterworth, D.M.
- Watkins, H.
- Witteman, J.C.
- Heijer, M. den
- Jacques, P.
- Uitterlinden, A.G.
- Kooner, J.S.
- Rader, D.J.
- Reilly, M.P.
- Mooser, V.
- Chasman, D.I.
- Samani, N.J.
- Ahmadi, K.R.
DOIAbstract
BACKGROUND: The strong observational association between total homocysteine (tHcy) concentrations and risk of coronary artery disease (CAD) and the null associations in the homocysteine-lowering trials have prompted the need to identify genetic variants associated with homocysteine concentrations and risk of CAD. OBJECTIVE: We tested whether common genetic polymorphisms associated with variation in tHcy are also associated with CAD. DESIGN: We conducted a meta-analysis of genome-wide association studies (GWAS) on tHcy concentrations in 44,147 individuals of European descent. Polymorphisms associated with tHcy (P < 10(-8)) were tested for association with CAD in 31,400 cases and 92,927 controls. RESULTS: Common variants at 13 loci, explainin...
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