The use of a new compound - TMB-4 Cl2 - in the protection of armin poisoned mice

Ispitao je TMB-4 CJ2 [1,3-trimetilcnbis(4-formil piridinijum hlorid) dioksim] kao zaštitno sredstvo kod miševa otrovanih arminom. TMB-4 Cl2, t. t. 235° C (nekor.), dobiven je iz TMB-4 [l,3-trimetilen-bis( 4-fonnilpiridinijum bromid)dioksim] i AgCI. Molekularni ekstinkcioni koeficijenat na 280 mµ je 32380, pK = 8,28; rastvorljivost u vodi 2 : 3. LD50 za bele miševe mužjake i ženke iznosi 88 (73-105) mg/kg. Zaštitna moć kod miševa otrovanih arminom i reaktivatorsko dejstvo na ChE celokupne krvi i mozga otrovanih miševa in vivo i na inhibiranu ChE plazme i eritrocita zeca in vitro isti su kao i rezultati koje su autori ranije objavili istražujući zaštitno dejstvo TMB-4.The protective effect of TMB-4 Cl2 [1,3-trimethylene bis (4-formil pyridine chloride) dioxime] in mice poisoned by armin [4-fonnyl (ethyl-p-nitrophenyl ethylphosphonate)] was studied. TMB-4 Cl2, m. p. 235° C (uncor.) was obtained from TMB-4 [1,3-trimethylene his (4-formyl pyridine bromide) dioxime] and AgCI. The molecular extinction per 280 mµ was 32380, pK = 8.28; solubility in water 2:3, LD50 in male and female albino mice was 88 (73-105) mg/kg. The protective effect of TMB-4 CI2 on armin poisoned mice and its reactivation effect on ChE of the whole blood and the brain of the poisoned mice in vivo, as well as on the inhibited ChE of the plasma and erythrocytes of the rabbits in vitro have proved the same as the effects obtained by the authors in the earlier experiments with TMB-4