Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel
- Mitt, Mario
- Kals, Mart
- Parn, Kalle
- Gabriel, Stacey B.
- Lander, Eric S.
- Palotie, Aarno
- Ripatti, Samuli
- Morris, Andrew P.
- Metspalu, Andres
- Esko, Tonu
- Magi, Reedik
- Palta, Priit
Publication date
June 2017
DOI Publisher
Springer Science and Business Media LLC ISSN
1018-4813 Citation count (estimate)
5Abstract
Genetic imputation is a cost-efficient way to improve the power and resolution of genome-wide association (GWA) studies. Current publicly accessible imputation reference panels accurately predict genotypes for common variants with minor allele frequency (MAF) >= 5% and low-frequency variants (0.5Peer reviewe
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