The paper deals with the seismic reliability of structural systems equipped with friction pendulum isolators (FPS). The behavior of these systems is analyzed by employing a two-degree-of-freedom model accounting for the superstructure flexibility, whereas the FPS isolator behaviour is described by adopting a widespread model which considers the variation of the friction coefficient with the velocity. The uncertainty in the seismic inputs is taken into account by employing a set of synthetic records, obtained through Monte Carlo simulations within the power spectral density method, with different characteristics depending on the soil dynamic parameters, and scaled to increasing intensity levels. The friction coefficient at large velocity is ...