The friction pendulum system (FPS) is becoming a widely used technique for seismic protection and retrofit of buildings, bridges and industrial structures. Experimental data also showed that the coefficient of friction depends on several effects (i.e., sliding velocity, apparent pressure, air temperature, cycling effect) so that it can be assumed as a random variable. The aim of the study consists in evaluating the seismic reliability of a 3D base-isolated structure with FP isolators considering both isolator properties (i.e., coefficient of friction) and earthquake main characteristics as random variables. Assuming appropriate density probability functions for each random variable and adopting the Latin Hypercube Sampling (LHS) method for ...