Spatial frequency reuse is a long-established approach for enhancing the capacity of wireless systems through increased spectral efficiency (bits per second per unit bandwidth). The future 5th generation of wireless systems is expected to incorporate various forms of frequency reuse. This includes multiple-input multiple-output (MIMO) communication enabling frequency reuse across antennas, device-to-device (D2D)-based densification allowing spectrum reuse across direct communication links, and full duplexing utilizing the same spectrum for communication in the transmit and receive directions. This dissertation aims at determining the performance limits of emerging wireless systems underpinned by dense spatial frequency reuse and interfer...