SummaryStress-regulated signaling pathways protect mitochondrial proteostasis and function from pathologic insults. Despite the importance of stress-regulated signaling pathways in mitochondrial proteome maintenance, the molecular mechanisms by which these pathways maintain mitochondrial proteostasis remain largely unknown. We identify Tim17A as a stress-regulated subunit of the translocase of the inner membrane 23 (TIM23) mitochondrial protein import complex. We show that Tim17A protein levels are decreased downstream of stress-regulated translational attenuation induced by eukaryotic initiation factor 2α (eIF2α) phosphorylation through a mechanism dependent on the mitochondrial protease YME1L. Furthermore, we demonstrate that decreasing T...
The mitochondrial unfolded protein response (UPR mt ) is an important stress response that ensures t...
Mitochondria, the main site of cellular energy harvesting, are derived from proteobacteria that evol...
Mitochondrial unfolded protein response is a form of retrograde signaling that contributes to ensuri...
SummaryStress-regulated signaling pathways protect mitochondrial proteostasis and function from path...
Mitochondrial and cytosolic proteostasis are of central relevance for cellular stress resistance and...
The unfolded protein response (UPRmt) rebalances mitochondrial protein homeostasis upon proteotoxic ...
Most of the mitochondrial proteome originates from nuclear genes and is transported into the mitocho...
The production of newly synthesized proteins is vital for all cellular functions and is a determinan...
The induction of the mitochondrial unfolded protein response (UPRmt) results in increased transcript...
Haploid genetic screening of cells under different types of mitochondrial perturbation shows that a ...
Mechanisms maintaining mitochondrial integrity range from specific repair pathways to wholesale degr...
Maintenance of mitochondrial gene expression is crucial for cellular homeostasis. Stress conditions...
SummaryThe mitochondrial inner membrane proteases YME1L and OMA1 are critical regulators of essentia...
Mitochondria fulfill central functions in bioenergetics, metabolism, and apoptosis. They import more...
In mammalian cells, mitochondrial dysfunction triggers the integrated stress response, in which the ...
The mitochondrial unfolded protein response (UPR mt ) is an important stress response that ensures t...
Mitochondria, the main site of cellular energy harvesting, are derived from proteobacteria that evol...
Mitochondrial unfolded protein response is a form of retrograde signaling that contributes to ensuri...
SummaryStress-regulated signaling pathways protect mitochondrial proteostasis and function from path...
Mitochondrial and cytosolic proteostasis are of central relevance for cellular stress resistance and...
The unfolded protein response (UPRmt) rebalances mitochondrial protein homeostasis upon proteotoxic ...
Most of the mitochondrial proteome originates from nuclear genes and is transported into the mitocho...
The production of newly synthesized proteins is vital for all cellular functions and is a determinan...
The induction of the mitochondrial unfolded protein response (UPRmt) results in increased transcript...
Haploid genetic screening of cells under different types of mitochondrial perturbation shows that a ...
Mechanisms maintaining mitochondrial integrity range from specific repair pathways to wholesale degr...
Maintenance of mitochondrial gene expression is crucial for cellular homeostasis. Stress conditions...
SummaryThe mitochondrial inner membrane proteases YME1L and OMA1 are critical regulators of essentia...
Mitochondria fulfill central functions in bioenergetics, metabolism, and apoptosis. They import more...
In mammalian cells, mitochondrial dysfunction triggers the integrated stress response, in which the ...
The mitochondrial unfolded protein response (UPR mt ) is an important stress response that ensures t...
Mitochondria, the main site of cellular energy harvesting, are derived from proteobacteria that evol...
Mitochondrial unfolded protein response is a form of retrograde signaling that contributes to ensuri...