SummaryAmplification of the ErbB2 locus, which encodes a receptor tyrosine kinase, is common in aggressive breast tumors and correlates with poor prognosis. The mechanisms underlying ErbB2-mediated breast carcinoma progression remain incompletely defined. To examine the role of the signaling and cell-adhesion receptor β4 integrin during ErbB2-mediated tumorigenesis, we introduced a targeted deletion of the β4 signaling domain into a mouse model of ErbB2-induced mammary carcinoma. Loss of β4 signaling suppresses mammary tumor onset and invasive growth. Ex vivo studies indicate that β4 forms a complex with ErbB2 and enhances activation of the transcription factors STAT3 and c-Jun. STAT3 contributes to disruption of epithelial adhesion and pol...
Overexpression of c-erbB-2 gene-encoded p185 has been correlated with lymph node metastasis and poor...
ERBB2 is a member of the ERBB family of tyrosine kinase receptors that plays a major role in breast ...
Estrogen receptors (ERs) have pivotal roles in the development and progression of triple-negative br...
SummaryAmplification of the ErbB2 locus, which encodes a receptor tyrosine kinase, is common in aggr...
Integrins modulate signaling by growth factor receptors, but their role during tumorigenesis is not ...
Integrins modulate signaling by growth factor receptors, but their role during tumorigenesis is not ...
AbstractWe have previously shown that human breast cancer cells that overexpress erbB-2 are growth f...
Integrins modulate signaling by growth factor receptors, but their role during tumorigenesis is not ...
AbstractDespite evidence demonstrating the role of β1-integrin in the regulation of cancer cell prol...
SummaryErbB2, a metastasis-promoting oncoprotein, is overexpressed in ∼25% of invasive/metastatic br...
Estrogen induces ERα-positive breast cancer aggressiveness via the promotion of cell proliferation a...
The integrin α6β4 (referred to as β4) is expressed in epithelial cells where it functions as a lamin...
AbstractErbB2+ human breast cancer is a major clinical problem. Prior results have suggested that te...
Overexpression of c-erbB-2 gene-encoded p185 has been correlated with lymph node metastasis and poor...
Overexpression of c-erbB-2 gene-encoded p185 has been correlated with lymph node metastasis and poor...
Overexpression of c-erbB-2 gene-encoded p185 has been correlated with lymph node metastasis and poor...
ERBB2 is a member of the ERBB family of tyrosine kinase receptors that plays a major role in breast ...
Estrogen receptors (ERs) have pivotal roles in the development and progression of triple-negative br...
SummaryAmplification of the ErbB2 locus, which encodes a receptor tyrosine kinase, is common in aggr...
Integrins modulate signaling by growth factor receptors, but their role during tumorigenesis is not ...
Integrins modulate signaling by growth factor receptors, but their role during tumorigenesis is not ...
AbstractWe have previously shown that human breast cancer cells that overexpress erbB-2 are growth f...
Integrins modulate signaling by growth factor receptors, but their role during tumorigenesis is not ...
AbstractDespite evidence demonstrating the role of β1-integrin in the regulation of cancer cell prol...
SummaryErbB2, a metastasis-promoting oncoprotein, is overexpressed in ∼25% of invasive/metastatic br...
Estrogen induces ERα-positive breast cancer aggressiveness via the promotion of cell proliferation a...
The integrin α6β4 (referred to as β4) is expressed in epithelial cells where it functions as a lamin...
AbstractErbB2+ human breast cancer is a major clinical problem. Prior results have suggested that te...
Overexpression of c-erbB-2 gene-encoded p185 has been correlated with lymph node metastasis and poor...
Overexpression of c-erbB-2 gene-encoded p185 has been correlated with lymph node metastasis and poor...
Overexpression of c-erbB-2 gene-encoded p185 has been correlated with lymph node metastasis and poor...
ERBB2 is a member of the ERBB family of tyrosine kinase receptors that plays a major role in breast ...
Estrogen receptors (ERs) have pivotal roles in the development and progression of triple-negative br...