Primary and booster immunization with a diphtheria, tetanus, acellular pertussis, hepatitis B (DTPa–HBV) and Haemophilus influenzae type b (Hib) vaccine administered separately or together is safe and immunogenic
- Marshall, Helen
- McIntyre, Peter
- Roberton, Don
- Dinan, Leonie
- Hardt, Karin
DOIAbstract
SummaryObjectivesThe aim of this study was to evaluate the safety and immunogenicity of DTPa–HBV and Hib vaccines given mixed or separately to 360 healthy infants at 2, 4, and 6 months of age.MethodsImmune memory was assessed in lower responders (post-primary anti-PRP <0.545μg/ml), through administration of plain polyribosylribitol phosphate (PRP) at 12–15 months. All subjects received a DTPa–HBV/Hib booster at 18–19 months.ResultsOne month after primary vaccination, 98% had seroprotective antibody levels against HBV and 94–97% against Hib (anti-PRP≥0.15μg/ml). A statistically significant difference between groups was observed in the proportion of subjects who achieved anti-PRP antibodies ≥1.0μg/ml post-primary vaccination; 68.1% for DTPa–H...
Add to ORKG