Primary and booster immunization with a diphtheria, tetanus, acellular pertussis, hepatitis B (DTPa-HBV) and Haemophilus influenzae type b (Hib) vaccine administered separately or together is safe and immunogenic
- Marshall, H.
- McIntyre, P.
- Roberton, D.
- Dinan, L.
- Hardt, K.
DOIAbstract
Copyright © 2009 International Society for Infectious Diseases Published by Elsevier Ltd.Objectives: The aim of this study was to evaluate the safety and immunogenicity of DTPa–HBV and Hib vaccines given mixed or separately to 360 healthy infants at 2, 4, and 6 months of age. Methods: Immune memory was assessed in lower responders (post-primary anti-PRP <0.545 μg/ml), through administration of plain polyribosylribitol phosphate (PRP) at 12–15 months. All subjects received a DTPa–HBV/Hib booster at 18–19 months. Results: One month after primary vaccination, 98% had seroprotective antibody levels against HBV and 94–97% against Hib (anti-PRP ≥ 0.15 μg/ml). A statistically significant difference between groups was observed in the proportion of ...
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