In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to autoimmunity
Thesis (Ph.D.)--University of Washington, 2014CD4+ regulatory T (Treg) cells expressing the transcri...
This Dissertation is broken into four chapters. In chapter 1 is an introduction into the thesis. In ...
Innate immune sensing of viral nucleic acids triggers type I interferon (IFN) production, which acti...
In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune resp...
SummaryDetection of nucleic acids and induction of type I interferons (IFNs) are principal elements ...
SummaryThe type I interferon (IFN) response initiated by detection of nucleic acids is important for...
SummaryTrex1 is the major 3′ DNA exonuclease in mammalian cells, and mutations in the human TREX1 ge...
Defects of the intracellular enzyme 3' repair exonuclease 1 (Trex1) cause the rare autoimmune condit...
Aicardi-Goutieres syndrome (AGS) is an unusual condition that clinically mimics a congenital viral i...
Abstract Background Both Aicardi-Goutières syndrome, a Mendelian mimic of congenital infection, and ...
SummaryTREX1 is an endoplasmic reticulum (ER)-associated negative regulator of innate immunity. TREX...
If DNA accumulates in the cytosol, it activates innate immunity via recently described DNA sensors. ...
Thesis (Ph.D.)--University of Washington, 2012Viruses infect all living organisms. Therefore, hosts ...
Three-prime repair exonuclease 1 (TREX1) is an anti-viral enzyme that cleaves nucleic acids in the c...
Microbial nucleic acid recognition serves as the major stimulus to an antiviral response, implying a...
Thesis (Ph.D.)--University of Washington, 2014CD4+ regulatory T (Treg) cells expressing the transcri...
This Dissertation is broken into four chapters. In chapter 1 is an introduction into the thesis. In ...
Innate immune sensing of viral nucleic acids triggers type I interferon (IFN) production, which acti...
In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune resp...
SummaryDetection of nucleic acids and induction of type I interferons (IFNs) are principal elements ...
SummaryThe type I interferon (IFN) response initiated by detection of nucleic acids is important for...
SummaryTrex1 is the major 3′ DNA exonuclease in mammalian cells, and mutations in the human TREX1 ge...
Defects of the intracellular enzyme 3' repair exonuclease 1 (Trex1) cause the rare autoimmune condit...
Aicardi-Goutieres syndrome (AGS) is an unusual condition that clinically mimics a congenital viral i...
Abstract Background Both Aicardi-Goutières syndrome, a Mendelian mimic of congenital infection, and ...
SummaryTREX1 is an endoplasmic reticulum (ER)-associated negative regulator of innate immunity. TREX...
If DNA accumulates in the cytosol, it activates innate immunity via recently described DNA sensors. ...
Thesis (Ph.D.)--University of Washington, 2012Viruses infect all living organisms. Therefore, hosts ...
Three-prime repair exonuclease 1 (TREX1) is an anti-viral enzyme that cleaves nucleic acids in the c...
Microbial nucleic acid recognition serves as the major stimulus to an antiviral response, implying a...
Thesis (Ph.D.)--University of Washington, 2014CD4+ regulatory T (Treg) cells expressing the transcri...
This Dissertation is broken into four chapters. In chapter 1 is an introduction into the thesis. In ...
Innate immune sensing of viral nucleic acids triggers type I interferon (IFN) production, which acti...
DOI
Add to ORKG