If DNA accumulates in the cytosol, it activates innate immunity via recently described DNA sensors. In this issue of Immunity, Gehrke et al. (2013) show that oxidized DNA is resistant to degradation by TREX1 and thus has heightened immunostimulatory capacity
Thesis (Ph.D.)--University of Washington, 2012Viruses infect all living organisms. Therefore, hosts ...
Autophagy can degrade intracellular bacteria, but how this pathway contributes to phagocytosis is un...
SummaryThe type I interferon (IFN) response initiated by detection of nucleic acids is important for...
If DNA accumulates in the cytosol, it activates innate immunity via recently described DNA sensors. ...
SummaryImmune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune dise...
SummaryDetection of nucleic acids and induction of type I interferons (IFNs) are principal elements ...
Recognition of foreign DNA in intracellular compartments or in the cytoplasm sounds an alarm bell si...
TREX1 regulates innate immune responses by counteracting DNA accumulation in the cytosol. In this is...
In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune resp...
Although it has been appreciated for some years that cytosolic DNA is immune stimulatory, it is only...
Recognition of microbial nucleic acids is one strategy by which mammalian hosts respond to infectiou...
SummaryTrex1 is the major 3′ DNA exonuclease in mammalian cells, and mutations in the human TREX1 ge...
Trex1, a major 3′ DNA exonuclease in mammalian cells, has been thought to act primarily in DNA repli...
Viral infection triggers innate immune sensors to produce type I interferons (IFN). However, HIV inf...
Viral infection triggers innate immune sensors to produce type I interferons (IFN). However, HIV inf...
Thesis (Ph.D.)--University of Washington, 2012Viruses infect all living organisms. Therefore, hosts ...
Autophagy can degrade intracellular bacteria, but how this pathway contributes to phagocytosis is un...
SummaryThe type I interferon (IFN) response initiated by detection of nucleic acids is important for...
If DNA accumulates in the cytosol, it activates innate immunity via recently described DNA sensors. ...
SummaryImmune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune dise...
SummaryDetection of nucleic acids and induction of type I interferons (IFNs) are principal elements ...
Recognition of foreign DNA in intracellular compartments or in the cytoplasm sounds an alarm bell si...
TREX1 regulates innate immune responses by counteracting DNA accumulation in the cytosol. In this is...
In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune resp...
Although it has been appreciated for some years that cytosolic DNA is immune stimulatory, it is only...
Recognition of microbial nucleic acids is one strategy by which mammalian hosts respond to infectiou...
SummaryTrex1 is the major 3′ DNA exonuclease in mammalian cells, and mutations in the human TREX1 ge...
Trex1, a major 3′ DNA exonuclease in mammalian cells, has been thought to act primarily in DNA repli...
Viral infection triggers innate immune sensors to produce type I interferons (IFN). However, HIV inf...
Viral infection triggers innate immune sensors to produce type I interferons (IFN). However, HIV inf...
Thesis (Ph.D.)--University of Washington, 2012Viruses infect all living organisms. Therefore, hosts ...
Autophagy can degrade intracellular bacteria, but how this pathway contributes to phagocytosis is un...
SummaryThe type I interferon (IFN) response initiated by detection of nucleic acids is important for...
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