Surrogate Endpoints in Second-Line Trials of Targeted Agents in Metastatic Colorectal Cancer: A Literature-Based Systematic Review and Meta-Analysis

CREMOLINI, CHIARA
ANTONIOTTI, CARLOTTA
Pietrantonio, Filippo
Berenato, Rosa
Tampellini, Marco
Baratelli, Chiara
Salvatore, Lisa
MARMORINO, FEDERICA
Borelli, Beatrice
Nichetti, Federico
Bironzo, Paolo
Sonetto, Cristina
Bartolomeo, Maria Di
de Braud, Filippo
Loupakis, Fotios
FALCONE, ALFREDO
Maio, Massimo Di

Open PDF

Open link

Publication date

January 2017

DOI

10.4143/crt.2016.249

ISSN

1598-2998

Language

English

Citation count (estimate)

Abstract

To evaluate progression-free survival (PFS) and objective response rate (ORR) as surrogate endpoints of overall survival (OS) in modern clinical trials investigating the efficacy of targeted agents in the second-line treatment of metastatic colorectal cancer (mCRC)

Extracted data

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Surrogate Endpoints in Second-Line Trials of Targeted Agents in Metastatic Colorectal Cancer: A Literature-Based Systematic Review and Meta-Analysis

CREMOLINI, CHIARA
ANTONIOTTI, CARLOTTA
Pietrantonio, Filippo
Berenato, Rosa
Tampellini, Marco
Baratelli, Chiara
Salvatore, Lisa
MARMORINO, FEDERICA
Borelli, Beatrice
Nichetti, Federico
Bironzo, Paolo
Sonetto, Cristina
Bartolomeo, Maria Di
de Braud, Filippo
Loupakis, Fotios
FALCONE, ALFREDO
Maio, Massimo Di

Open PDF

Open link

Publication date

January 2017

DOI

10.4143/crt.2016.249

ISSN

1598-2998

Language

English

Citation count (estimate)

Abstract

Extracted data

Topics

progression-free survival

colorectal cancerDisease

A. Sartore-Bianchi
A. Amatu
E. Bonazzina
S. Stabile
L. Giannetta
G. Cerea
I. Schiavetto
K. Bencardino
C. Funaioli
R. Ricotta
T. Cipani
M. Schirru
V. Gambi
L. Palmeri
G. Carlo-Stella
F. Rusconi
S. Di Bella
G. Burrafato
A. Cassingena
E. Valtorta
C. Lauricella
F. Pazzi
A. Gambaro
S. Ghezzi
G. Marrapese
E. Tarenzi
S. Veronese
M. Truini
A. Vanzulli
S. Siena

January 2017

BACKGROUND: Patients with metastatic colorectal cancer (mCRC) refractory to standard therapies have ...

Surrogate Endpoints in Second-Line Trials of Targeted Agents in Metastatic Colorectal Cancer: A Literature-Based Systematic Review and Meta-Analysis

CREMOLINI, CHIARA
ANTONIOTTI, CARLOTTA
Pietrantonio, Filippo
Berenato, Rosa
Tampellini, Marco
Baratelli, Chiara
Salvatore, Lisa
MARMORINO, FEDERICA
Borelli, Beatrice
Nichetti, Federico
Bironzo, Paolo
Sonetto, Cristina
Bartolomeo, Maria Di
de Braud, Filippo
Loupakis, Fotios
FALCONE, ALFREDO
Maio, Massimo Di

January 2017

To evaluate progression-free survival (PFS) and objective response rate (ORR) as surrogate endpoints...

Surrogate Endpoints in Second-Line Trials of Targeted Agents in Metastatic Colorectal Cancer : A Literature-Based Systematic Review and Meta-Analysis

C. Cremolini
C. Antoniotti
F. Pietrantonio
R. Berenato
M. Tampellini
C. Baratelli
L. Salvatore
F. Marmorino
B. Borelli
F. Nichetti
P. Bironzo
C. Sonetto
M.D. Bartolomeo
F. de Braud
F. Loupakis
A. Falcone
M.D. Maio

July 2017

The purpose of this study was to evaluate progression-free survival (PFS) and objective response rat...

Progression-free survival as a surrogate endpoint of overall survival in patients with metastatic colorectal cancer

Cicero, Giuseppe
De Luca, Rossella
Dieli, Francesco

January 2018

Background: In many clinical trials designed to assess the efficacy of anticancer treatments, overal...

Evaluation of Continuous Tumor-Size-Based End Points as Surrogates for Overall Survival in Randomized Clinical Trials in Metastatic Colorectal Cancer

Burzykowski T.
Coart E.
Saad E. D.
Shi Q.
Sommeijer D. W.
Bokemeyer C.
Diaz-Rubio E.
Douillard J. -Y.
Falcone A.
Fuchs C. S.
Goldberg R. M.
Hecht J. R.
Hoff P. M.
Hurwitz H.
Kabbinavar F. F.
Koopman M.
Maughan T. S.
Punt C. J. A.
Saltz L.
Schmoll H. -J.
Seymour M. T.
Tebbutt N. C.
Tournigand C.
Van Cutsem E.
de Gramont A.
Zalcberg J. R.
Buyse M.

January 2019

Importance: Tumor measurements can be used to estimate time to nadir and depth of nadir as potential...

Individual patient data analysis of progression-free survival versus overall survival as a first-line end point for metastatic colorectal cancer in modern randomized trials: findings from the analysis and research in cancers of the digestive system database

Shi, Qian
de Gramont, Aimery
Grothey, Axel
Zalcberg, John
Chibaudel, Benoist
Schmoll, Hans-Joachim
Seymour, Matthew T.
Adams, Richard
Saltz, Leonard
Goldberg, Richard M.
Punt, Cornelis J.A.
Douillard, Jean-Yves
Hoff, Paulo M.
Hecht, Joel Randolph
Hurwitz, Herbert
Diaz-Rubio, Eduardo
Porschen, Rainer
Tebbutt, Niall C.
Fuchs, Charles
Souglakos, John
Falcone, Alfredo
Tournigand, Christophe
Kabbinavar, Fairooz F.
Heinemann, Volker
Van Cutsem, Eric
Bokemeyer, Carsten
Buyse, Marc
Sargent, Daniel J.

January 2015

Purpose Progression-free survival (PFS) has previously been established as a surrogate for overall s...

Individual patient data analysis of progression-free survival versus overall survival as a first-line end point for metastatic colorectal cancer in modern randomized trials: Findings from the analysis and research in cancers of the digestive system database

Shi, Qian
De Gramont, Aimery
Grothey, Axel
Zalcberg, John
Chibaudel, Benoist
Schmoll, Hans-Joachim
Seymour, Matthew T.
Adams, Richard
Saltz, Leonard
Goldberg, Richard M.
Punt, Cornelis J.A.
Douillard, Jean-Yves
Hoff, Paulo M.
Hecht, Joel Randolph
Hurwitz, Herbert
Díaz-Rubio, Eduardo
Porschen, Rainer
Tebbutt, Niall C.
Fuchs, Charles
Souglakos, John
Falcone, Alfredo
Tournigand, Christophe
Kabbinavar, Fairooz F.
Heinemann, Volker
Van Cutsem, Eric
Bokemeyer, Carsten
Buyse, Marc
Sargent, Daniel J.

January 2015

PURPOSE: Progression-free survival (PFS) has previously been established as a surrogate for over...

Evaluation of Continuous Tumor-Size–Based End Points as Surrogates for Overall Survival in Randomized Clinical Trials in Metastatic Colorectal Cancer

Burzykowski, T
Coart, E
Saad, ED
Shi, Q
Sommeijer, DW
Bokemeyer, C
Díaz-Rubio, E
Douillard, J-Y
Falcone, A
Fuchs, CS
Goldberg, RM
Hecht, JR
Hoff, PM
Hurwitz, H
Kabbinavar, FF
Koopman, M
Maughan, TS
Punt, CJA
Saltz, L
Schmoll, H-J
Seymour, MT
Tebbutt, NC
Tournigand, C
Van Cutsem, E
de Gramont, A
Zalcberg, JR
Buyse, M

September 2019

Importance Tumor measurements can be used to estimate time to nadir and depth of nadir as potential...

A. Sartore-Bianchi
A. Amatu
E. Bonazzina
S. Stabile
L. Giannetta
G. Cerea
I. Schiavetto
K. Bencardino
C. Funaioli
R. Ricotta
T. Cipani
M. Schirru
V. Gambi
L. Palmeri
G. Carlo-Stella
F. Rusconi
S. Di Bella
G. Burrafato
A. Cassingena
E. Valtorta
C. Lauricella
F. Pazzi
A. Gambaro
S. Ghezzi
G. Marrapese
E. Tarenzi
S. Veronese
M. Truini
A. Vanzulli
S. Siena

January 2017

BACKGROUND: Patients with metastatic colorectal cancer (mCRC) refractory to standard therapies have ...

Surrogate Endpoints in Second-Line Trials of Targeted Agents in Metastatic Colorectal Cancer: A Literature-Based Systematic Review and Meta-Analysis

CREMOLINI, CHIARA
ANTONIOTTI, CARLOTTA
Pietrantonio, Filippo
Berenato, Rosa
Tampellini, Marco
Baratelli, Chiara
Salvatore, Lisa
MARMORINO, FEDERICA
Borelli, Beatrice
Nichetti, Federico
Bironzo, Paolo
Sonetto, Cristina
Bartolomeo, Maria Di
de Braud, Filippo
Loupakis, Fotios
FALCONE, ALFREDO
Maio, Massimo Di

January 2017

To evaluate progression-free survival (PFS) and objective response rate (ORR) as surrogate endpoints...

Surrogate Endpoints in Second-Line Trials of Targeted Agents in Metastatic Colorectal Cancer : A Literature-Based Systematic Review and Meta-Analysis

C. Cremolini
C. Antoniotti
F. Pietrantonio
R. Berenato
M. Tampellini
C. Baratelli
L. Salvatore
F. Marmorino
B. Borelli
F. Nichetti
P. Bironzo
C. Sonetto
M.D. Bartolomeo
F. de Braud
F. Loupakis
A. Falcone
M.D. Maio

July 2017

The purpose of this study was to evaluate progression-free survival (PFS) and objective response rat...

Evaluation of Continuous Tumor-Size-Based End Points as Surrogates for Overall Survival in Randomized Clinical Trials in Metastatic Colorectal Cancer

Burzykowski T.
Coart E.
Saad E. D.
Shi Q.
Sommeijer D. W.
Bokemeyer C.
Diaz-Rubio E.
Douillard J. -Y.
Falcone A.
Fuchs C. S.
Goldberg R. M.
Hecht J. R.
Hoff P. M.
Hurwitz H.
Kabbinavar F. F.
Koopman M.
Maughan T. S.
Punt C. J. A.
Saltz L.
Schmoll H. -J.
Seymour M. T.
Tebbutt N. C.
Tournigand C.
Van Cutsem E.
de Gramont A.
Zalcberg J. R.
Buyse M.

January 2019

Importance: Tumor measurements can be used to estimate time to nadir and depth of nadir as potential...

Shi, Qian
de Gramont, Aimery
Grothey, Axel
Zalcberg, John
Chibaudel, Benoist
Schmoll, Hans-Joachim
Seymour, Matthew T.
Adams, Richard
Saltz, Leonard
Goldberg, Richard M.
Punt, Cornelis J.A.
Douillard, Jean-Yves
Hoff, Paulo M.
Hecht, Joel Randolph
Hurwitz, Herbert
Diaz-Rubio, Eduardo
Porschen, Rainer
Tebbutt, Niall C.
Fuchs, Charles
Souglakos, John
Falcone, Alfredo
Tournigand, Christophe
Kabbinavar, Fairooz F.
Heinemann, Volker
Van Cutsem, Eric
Bokemeyer, Carsten
Buyse, Marc
Sargent, Daniel J.

January 2015

Purpose Progression-free survival (PFS) has previously been established as a surrogate for overall s...

Individual patient data analysis of progression-free survival versus overall survival as a first-line end point for metastatic colorectal cancer in modern randomized trials: Findings from the analysis and research in cancers of the digestive system database

Shi, Qian
De Gramont, Aimery
Grothey, Axel
Zalcberg, John
Chibaudel, Benoist
Schmoll, Hans-Joachim
Seymour, Matthew T.
Adams, Richard
Saltz, Leonard
Goldberg, Richard M.
Punt, Cornelis J.A.
Douillard, Jean-Yves
Hoff, Paulo M.
Hecht, Joel Randolph
Hurwitz, Herbert
Díaz-Rubio, Eduardo
Porschen, Rainer
Tebbutt, Niall C.
Fuchs, Charles
Souglakos, John
Falcone, Alfredo
Tournigand, Christophe
Kabbinavar, Fairooz F.
Heinemann, Volker
Van Cutsem, Eric
Bokemeyer, Carsten
Buyse, Marc
Sargent, Daniel J.

January 2015

PURPOSE: Progression-free survival (PFS) has previously been established as a surrogate for over...

Evaluation of Continuous Tumor-Size–Based End Points as Surrogates for Overall Survival in Randomized Clinical Trials in Metastatic Colorectal Cancer

Burzykowski, T
Coart, E
Saad, ED
Shi, Q
Sommeijer, DW
Bokemeyer, C
Díaz-Rubio, E
Douillard, J-Y
Falcone, A
Fuchs, CS
Goldberg, RM
Hecht, JR
Hoff, PM
Hurwitz, H
Kabbinavar, FF
Koopman, M
Maughan, TS
Punt, CJA
Saltz, L
Schmoll, H-J
Seymour, MT
Tebbutt, NC
Tournigand, C
Van Cutsem, E
de Gramont, A
Zalcberg, JR
Buyse, M

September 2019

Importance Tumor measurements can be used to estimate time to nadir and depth of nadir as potential...

A. Sartore-Bianchi
A. Amatu
E. Bonazzina
S. Stabile
L. Giannetta
G. Cerea
I. Schiavetto
K. Bencardino
C. Funaioli
R. Ricotta
T. Cipani
M. Schirru
V. Gambi
L. Palmeri
G. Carlo-Stella
F. Rusconi
S. Di Bella
G. Burrafato
A. Cassingena
E. Valtorta
C. Lauricella
F. Pazzi
A. Gambaro
S. Ghezzi
G. Marrapese
E. Tarenzi
S. Veronese
M. Truini
A. Vanzulli
S. Siena

January 2017

BACKGROUND: Patients with metastatic colorectal cancer (mCRC) refractory to standard therapies have ...

Related items

A. Sartore-Bianchi
A. Amatu
E. Bonazzina
S. Stabile
L. Giannetta
G. Cerea
I. Schiavetto
K. Bencardino
C. Funaioli
R. Ricotta
T. Cipani
M. Schirru
V. Gambi
L. Palmeri
G. Carlo-Stella
F. Rusconi
S. Di Bella
G. Burrafato
A. Cassingena
E. Valtorta
C. Lauricella
F. Pazzi
A. Gambaro
S. Ghezzi
G. Marrapese
E. Tarenzi
S. Veronese
M. Truini
A. Vanzulli
S. Siena

January 2017

BACKGROUND: Patients with metastatic colorectal cancer (mCRC) refractory to standard therapies have ...

Surrogate Endpoints in Second-Line Trials of Targeted Agents in Metastatic Colorectal Cancer: A Literature-Based Systematic Review and Meta-Analysis

CREMOLINI, CHIARA
ANTONIOTTI, CARLOTTA
Pietrantonio, Filippo
Berenato, Rosa
Tampellini, Marco
Baratelli, Chiara
Salvatore, Lisa
MARMORINO, FEDERICA
Borelli, Beatrice
Nichetti, Federico
Bironzo, Paolo
Sonetto, Cristina
Bartolomeo, Maria Di
de Braud, Filippo
Loupakis, Fotios
FALCONE, ALFREDO
Maio, Massimo Di

January 2017

To evaluate progression-free survival (PFS) and objective response rate (ORR) as surrogate endpoints...

Surrogate Endpoints in Second-Line Trials of Targeted Agents in Metastatic Colorectal Cancer : A Literature-Based Systematic Review and Meta-Analysis

C. Cremolini
C. Antoniotti
F. Pietrantonio
R. Berenato
M. Tampellini
C. Baratelli
L. Salvatore
F. Marmorino
B. Borelli
F. Nichetti
P. Bironzo
C. Sonetto
M.D. Bartolomeo
F. de Braud
F. Loupakis
A. Falcone
M.D. Maio

July 2017

The purpose of this study was to evaluate progression-free survival (PFS) and objective response rat...

Progression-free survival as a surrogate endpoint of overall survival in patients with metastatic colorectal cancer

Cicero, Giuseppe
De Luca, Rossella
Dieli, Francesco

January 2018

Background: In many clinical trials designed to assess the efficacy of anticancer treatments, overal...

Evaluation of Continuous Tumor-Size-Based End Points as Surrogates for Overall Survival in Randomized Clinical Trials in Metastatic Colorectal Cancer

Burzykowski T.
Coart E.
Saad E. D.
Shi Q.
Sommeijer D. W.
Bokemeyer C.
Diaz-Rubio E.
Douillard J. -Y.
Falcone A.
Fuchs C. S.
Goldberg R. M.
Hecht J. R.
Hoff P. M.
Hurwitz H.
Kabbinavar F. F.
Koopman M.
Maughan T. S.
Punt C. J. A.
Saltz L.
Schmoll H. -J.
Seymour M. T.
Tebbutt N. C.
Tournigand C.
Van Cutsem E.
de Gramont A.
Zalcberg J. R.
Buyse M.

January 2019

Importance: Tumor measurements can be used to estimate time to nadir and depth of nadir as potential...

Shi, Qian
de Gramont, Aimery
Grothey, Axel
Zalcberg, John
Chibaudel, Benoist
Schmoll, Hans-Joachim
Seymour, Matthew T.
Adams, Richard
Saltz, Leonard
Goldberg, Richard M.
Punt, Cornelis J.A.
Douillard, Jean-Yves
Hoff, Paulo M.
Hecht, Joel Randolph
Hurwitz, Herbert
Diaz-Rubio, Eduardo
Porschen, Rainer
Tebbutt, Niall C.
Fuchs, Charles
Souglakos, John
Falcone, Alfredo
Tournigand, Christophe
Kabbinavar, Fairooz F.
Heinemann, Volker
Van Cutsem, Eric
Bokemeyer, Carsten
Buyse, Marc
Sargent, Daniel J.

January 2015

Purpose Progression-free survival (PFS) has previously been established as a surrogate for overall s...

Individual patient data analysis of progression-free survival versus overall survival as a first-line end point for metastatic colorectal cancer in modern randomized trials: Findings from the analysis and research in cancers of the digestive system database

Shi, Qian
De Gramont, Aimery
Grothey, Axel
Zalcberg, John
Chibaudel, Benoist
Schmoll, Hans-Joachim
Seymour, Matthew T.
Adams, Richard
Saltz, Leonard
Goldberg, Richard M.
Punt, Cornelis J.A.
Douillard, Jean-Yves
Hoff, Paulo M.
Hecht, Joel Randolph
Hurwitz, Herbert
Díaz-Rubio, Eduardo
Porschen, Rainer
Tebbutt, Niall C.
Fuchs, Charles
Souglakos, John
Falcone, Alfredo
Tournigand, Christophe
Kabbinavar, Fairooz F.
Heinemann, Volker
Van Cutsem, Eric
Bokemeyer, Carsten
Buyse, Marc
Sargent, Daniel J.

January 2015

PURPOSE: Progression-free survival (PFS) has previously been established as a surrogate for over...

Evaluation of Continuous Tumor-Size–Based End Points as Surrogates for Overall Survival in Randomized Clinical Trials in Metastatic Colorectal Cancer

Burzykowski, T
Coart, E
Saad, ED
Shi, Q
Sommeijer, DW
Bokemeyer, C
Díaz-Rubio, E
Douillard, J-Y
Falcone, A
Fuchs, CS
Goldberg, RM
Hecht, JR
Hoff, PM
Hurwitz, H
Kabbinavar, FF
Koopman, M
Maughan, TS
Punt, CJA
Saltz, L
Schmoll, H-J
Seymour, MT
Tebbutt, NC
Tournigand, C
Van Cutsem, E
de Gramont, A
Zalcberg, JR
Buyse, M

September 2019

Importance Tumor measurements can be used to estimate time to nadir and depth of nadir as potential...

A. Sartore-Bianchi
A. Amatu
E. Bonazzina
S. Stabile
L. Giannetta
G. Cerea
I. Schiavetto
K. Bencardino
C. Funaioli
R. Ricotta
T. Cipani
M. Schirru
V. Gambi
L. Palmeri
G. Carlo-Stella
F. Rusconi
S. Di Bella
G. Burrafato
A. Cassingena
E. Valtorta
C. Lauricella
F. Pazzi
A. Gambaro
S. Ghezzi
G. Marrapese
E. Tarenzi
S. Veronese
M. Truini
A. Vanzulli
S. Siena

January 2017

BACKGROUND: Patients with metastatic colorectal cancer (mCRC) refractory to standard therapies have ...

Surrogate Endpoints in Second-Line Trials of Targeted Agents in Metastatic Colorectal Cancer: A Literature-Based Systematic Review and Meta-Analysis

CREMOLINI, CHIARA
ANTONIOTTI, CARLOTTA
Pietrantonio, Filippo
Berenato, Rosa
Tampellini, Marco
Baratelli, Chiara
Salvatore, Lisa
MARMORINO, FEDERICA
Borelli, Beatrice
Nichetti, Federico
Bironzo, Paolo
Sonetto, Cristina
Bartolomeo, Maria Di
de Braud, Filippo
Loupakis, Fotios
FALCONE, ALFREDO
Maio, Massimo Di

January 2017

To evaluate progression-free survival (PFS) and objective response rate (ORR) as surrogate endpoints...

Surrogate Endpoints in Second-Line Trials of Targeted Agents in Metastatic Colorectal Cancer : A Literature-Based Systematic Review and Meta-Analysis

C. Cremolini
C. Antoniotti
F. Pietrantonio
R. Berenato
M. Tampellini
C. Baratelli
L. Salvatore
F. Marmorino
B. Borelli
F. Nichetti
P. Bironzo
C. Sonetto
M.D. Bartolomeo
F. de Braud
F. Loupakis
A. Falcone
M.D. Maio

July 2017

The purpose of this study was to evaluate progression-free survival (PFS) and objective response rat...

Evaluation of Continuous Tumor-Size-Based End Points as Surrogates for Overall Survival in Randomized Clinical Trials in Metastatic Colorectal Cancer

Burzykowski T.
Coart E.
Saad E. D.
Shi Q.
Sommeijer D. W.
Bokemeyer C.
Diaz-Rubio E.
Douillard J. -Y.
Falcone A.
Fuchs C. S.
Goldberg R. M.
Hecht J. R.
Hoff P. M.
Hurwitz H.
Kabbinavar F. F.
Koopman M.
Maughan T. S.
Punt C. J. A.
Saltz L.
Schmoll H. -J.
Seymour M. T.
Tebbutt N. C.
Tournigand C.
Van Cutsem E.
de Gramont A.
Zalcberg J. R.
Buyse M.

January 2019

Importance: Tumor measurements can be used to estimate time to nadir and depth of nadir as potential...

Shi, Qian
de Gramont, Aimery
Grothey, Axel
Zalcberg, John
Chibaudel, Benoist
Schmoll, Hans-Joachim
Seymour, Matthew T.
Adams, Richard
Saltz, Leonard
Goldberg, Richard M.
Punt, Cornelis J.A.
Douillard, Jean-Yves
Hoff, Paulo M.
Hecht, Joel Randolph
Hurwitz, Herbert
Diaz-Rubio, Eduardo
Porschen, Rainer
Tebbutt, Niall C.
Fuchs, Charles
Souglakos, John
Falcone, Alfredo
Tournigand, Christophe
Kabbinavar, Fairooz F.
Heinemann, Volker
Van Cutsem, Eric
Bokemeyer, Carsten
Buyse, Marc
Sargent, Daniel J.

January 2015

Purpose Progression-free survival (PFS) has previously been established as a surrogate for overall s...

Individual patient data analysis of progression-free survival versus overall survival as a first-line end point for metastatic colorectal cancer in modern randomized trials: Findings from the analysis and research in cancers of the digestive system database

Shi, Qian
De Gramont, Aimery
Grothey, Axel
Zalcberg, John
Chibaudel, Benoist
Schmoll, Hans-Joachim
Seymour, Matthew T.
Adams, Richard
Saltz, Leonard
Goldberg, Richard M.
Punt, Cornelis J.A.
Douillard, Jean-Yves
Hoff, Paulo M.
Hecht, Joel Randolph
Hurwitz, Herbert
Díaz-Rubio, Eduardo
Porschen, Rainer
Tebbutt, Niall C.
Fuchs, Charles
Souglakos, John
Falcone, Alfredo
Tournigand, Christophe
Kabbinavar, Fairooz F.
Heinemann, Volker
Van Cutsem, Eric
Bokemeyer, Carsten
Buyse, Marc
Sargent, Daniel J.

January 2015

PURPOSE: Progression-free survival (PFS) has previously been established as a surrogate for over...

Evaluation of Continuous Tumor-Size–Based End Points as Surrogates for Overall Survival in Randomized Clinical Trials in Metastatic Colorectal Cancer

Burzykowski, T
Coart, E
Saad, ED
Shi, Q
Sommeijer, DW
Bokemeyer, C
Díaz-Rubio, E
Douillard, J-Y
Falcone, A
Fuchs, CS
Goldberg, RM
Hecht, JR
Hoff, PM
Hurwitz, H
Kabbinavar, FF
Koopman, M
Maughan, TS
Punt, CJA
Saltz, L
Schmoll, H-J
Seymour, MT
Tebbutt, NC
Tournigand, C
Van Cutsem, E
de Gramont, A
Zalcberg, JR
Buyse, M

September 2019

Importance Tumor measurements can be used to estimate time to nadir and depth of nadir as potential...

A. Sartore-Bianchi
A. Amatu
E. Bonazzina
S. Stabile
L. Giannetta
G. Cerea
I. Schiavetto
K. Bencardino
C. Funaioli
R. Ricotta
T. Cipani
M. Schirru
V. Gambi
L. Palmeri
G. Carlo-Stella
F. Rusconi
S. Di Bella
G. Burrafato
A. Cassingena
E. Valtorta
C. Lauricella
F. Pazzi
A. Gambaro
S. Ghezzi
G. Marrapese
E. Tarenzi
S. Veronese
M. Truini
A. Vanzulli
S. Siena

January 2017

BACKGROUND: Patients with metastatic colorectal cancer (mCRC) refractory to standard therapies have ...