Tracking instantaneous entropy in heartbeat dynamics through inhomogeneous point-process nonlinear models

Measures of entropy have been proved as powerful quantifiers of complex nonlinear systems, particularly when applied to stochastic series of heartbeat dynamics. Despite the remarkable achievements obtained through standard definitions of approximate and sample entropy, a time-varying definition of entropy characterizing the physiological dynamics at each moment in time is still missing. To this extent, we propose two novel measures of entropy based on the inho-mogeneous point-process theory. The RR interval series is modeled through probability density functions (pdfs) which characterize and predict the time until the next event occurs as a function of the past history. Laguerre expansions of the Wiener-Volterra autoregressive terms account for the long-term nonlinear information. As the proposed measures of entropy are instantaneously defined through such probability functions, the proposed indices are able to provide instantaneous tracking of autonomic nervous system complexity. Of note, the distance between the time-varying phase-space vectors is calculated through the Kolmogorov-Smirnov distance of two pdfs. Experimental results, obtained from the analysis of RR interval series extracted from ten healthy subjects during stand-up tasks, suggest that the proposed entropy indices provide instantaneous tracking of the heartbeat complexity, also allowing for the definition of complexity variability indices