Genetic Variation in the Carbonic Anhydrase Isozymes of Macaque Monkeys. II. Inheritance of Red Cell Carbonic Anhydrase Levels in Different Carbonic Anhydrase I Genotypes of the

The inheritance of red blood cell levels of carbonic anhydrase isozymes (CA I and CA II) has been studied in different carbonic anhydrase I genotypes of the pig-tailed macaque, Macaca nemestr ina. Quantitation of CA I isozymes in a series of animals indicates that the total CA I concentration is the sum of the average ffects of each CA I structural allele and that the average ffects are independent of the various allelie combinations. The relative average effects were 0.32:0.95:1.0 for the CA P, CA P, and CA I e structural genes, res-pectively. It is also demonstrated that the level of CA H is related to the CA I genotypes. Multiple regression analysis demonstrated that each dose of CA I-deficiency gene present decreased the CA H concentration by approximately 30%, with this decrease in CA H level being solely related to the dose of CA I-deficiency gene and not to the level of CA L The CA I-deficient animals produce CA I products that are similar to the common CA Ia, CA Ib, CA Ie electrophoretic types. Limited mating data indicate that the CA I components in CA I-deficient animals are inherited codominantly