Sequential [‘251J-o-lodohippurate Renograms from

Renography provides suitable monitoring of the transplanted kidney. Information on renal blood flow, tubular function, and urine excretion is gained, and minor disturbances are detected. It is a sensitive method, but it lacks specificity because numerous competitive factors cause similar changes in the renograms. In experimental models, controlled studies of any single factor can be made. In the present study the influence of warm ischemia on the renogram and kidney function under standardized conditions is investigated. MATERIAL AND METHODS Female rabbits of Danish landbreed, with an av erage weight of2.7 kg, were used in 42 experiments. The animals were anesthetized with Nembutal (R) 8—12 mg/kg. The blood pressure and abdominal temperature were registered and controlled during anesthesia. Preoperatively, isotonic NaCI (15 mI/kg) and heparin (500 lU/kg) were given intravenously. Oxygen and fluid supplements were given during the operation. Anesthesia was maintained with Nembutal, 2-4 mg/kg, every hour. The abdomen was opened in the midline and the kidney ap proached transperitoneally. The right kidney was removed, and a renogram of the left kidney per formed.The left renalartery wasthenclampedfor 0, 1, 1Â,2, 2Â,or 3 hr. The duration of ischemia in each experiment was allocated at random. Five minutes after renal circulation was restored, an other renogram was performed. The abdomen was then closed. In the control group the right kidney was removed, the left not touched, and the rabbit kept in anesthesia for 3 hr