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Two new brominated compounds, subereaphenol K (2) and 2-(3,5-dibromo-1-ethoxy-4-oxocyclo-hexa-2,5-dien-1-yl)acetamide (3), together with subereaphenol B (methyl 2-(2,4-dibromo-3,6-dihydroxy-phenyl)acetate; 1) with a revised structure, and five dibromotyrosine-derived metabolites, 4–8, were isolated from the sponge Suberea sp. and characterized by 1D- and 2D-NMR spectroscopic and HR-MS spectrometric data. Compounds 1, 2, 6, and 8 exhibited various weak or moderate bioactivities, including antimicrobial and cytotoxic activities. Furthermore, compounds 1 and 2 inhibited human recombinant phosphodiesterase 4 (PDE4) with IC50 values of 2 mm, whereas compounds 6 and 8 were less active. Introduction. – Over the past 50 years, marine sponges have been a prolific source of diverse secondary metabolites. Many natural products from sponges possess complex and unique structures with a variety of interesting biological activities, some of them with good potential for medical applications [1] [2]. Previous studies on the Red Sea sponge Suberea mollis (order Verongida, family Aplysinellidae) resulted in th