Brief Communication Delayed Hypersensitivity to Simian Virus 40 Tumor Cells in BALB IC Mice Demonstrated

SUMMARY-Inoculation of simian virus 40 tumor cells into the foot pad of tumor-immune mice induced a delayed hypersensitivity reaction, as measured by the escape of 1251_labeled serum protein into the interstitial fluids of the inflamed area. Passive transfer of the delayed hypersensitivity reaction was accomplished with spleen cells, but not serum, from tumor-immune animals.-J Nat Cancer Inst 48: 563-566, 1972. CUTANEOUS DELAYED hypersensitivity to viable tumor cells and tumor extracts has been used to detect immunity to chemically induced tumors in guinea pigs (1, 2), rats (3), and mice (4). Recently, delayed hypersensitivity to the intradermal inocu-lation of autologous tumor extracts has been demon-strated in humans with Burkitt's lymphoma, leu-kemia and lymphoma (5), fibrosarcoma, and carcinoma of the breast, colon, lung, stomach, an