Case Report Neonatal Alloimmune Thrombocytopenia Associated with

Abstract: Neonatal alloimmune thrombocytopenia (NAIT) is a result of platelet destruction by maternal antibodies directed against paternally-inherited antigens on neonatal platelets. NAIT is mostly caused by antibodies to human platelet antigens (HPA). This is a report of a term newborn with NAIT associated with an antibody to the human leukocyte antigens (HLA). The newborn presented with cutaneous bleeding at 5 days of age. The lowest platelet count was 36.8x109/L. An antibody to HLA-A11 was present in maternal serum while HPA antibodies were not detected. The HLA-A11 antigen was identified in the patient, sister, and father, but not the mother. The newborn received intravenous immunoglobulin and had a favorable outcome