A case of neonatal HPA-1b allo-immune thrombocytopenia

We present a case of a newborn with neonatal alloimmune thrombocytopenia (NAIT) due to fete-maternal incompatibility for the thrombocyte allo-antigen HPA-1b. We discuss the policy of platelet transfusions and suggest to treat NAIT early on with thrombocytes transfusions from selected compatible donors. We reviewed the literature and found no association between HLA phenotype and HPA-1b induced NAIT.