Trends in cancer mortality in Switzerland, 1980-2001

Trends in cancer mortality in Switzerland were analysed over the period 1980-2001, on the basis of the World Health Organization database. Appropriately developed correction factors were utilized for the period before 1995, to allow for spurious trends introduced by the change between the 8th and the 10th revisions of the ICD. Steady declines in cancer mortality were observed, particularly from the mid-1980s onwards. Over the last decade, the fall in overall age-standardized (world standard) cancer mortality was 11.1% in men (from 158.1 in 1990-1991 to 140.6/100 000 in 2000-2001) and 7.6% in women (from 91.6 to 84.7/100 000), and the decline was larger in truncated rates from 35 to 64 years (-18.0 and -9.7%). In men, all major tobacco and alcohol neoplasms have declined until the late 1990s but have levelled off over the last few years, reflecting recent trends in alcohol and tobacco consumption. The fall in male lung cancer mortality was 20% over the last decade (from 42.9 to 34.3/100 000). In contrast, lung cancer mortality in women has steadily increased by 38% between 1981 and 1991 and by 47% between 1991 and 2001, to reach 10.7/100 000 at all ages and 18.3 at age 35 to 64, due to increased prevalence of smoking in subsequent generations of Swiss women. Other sites showing substantial declines include stomach and colorectum in both sexes, (cervix) uteri and breast in women. Likewise, prostate cancer showed modest favourable trends after 1995. Steady declines were observed for leukaemias, Hodgkin's disease and testicular cancer, namely, the neoplasms most influenced by therapeutic improvements, while trends in lymphomas and myeloma showed no clear pattern. [Authors]]]> Neoplasms oai:serval.unil.ch:BIB_4FDAD003069F 2022-05-07T01:17:43Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_4FDAD003069F The Arid Margins of Northern Syria: Land Occupation and Modes of Exploitation in the Bronze Age Geyer, B. Al-Dbiyat, M. Awad, N. Barge, O. Besançon, J. Jaubert, R. info:eu-repo/semantics/bookPart incollection 2008 Urban and Natural Landscapes of an Ancient Syrian Capital, Settlement and Environment at Tell Mishrifeh/Qatna and in Central-Western Syria oai:serval.unil.ch:BIB_4FDAF0543B78 2022-05-07T01:17:43Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_4FDAF0543B78 Adverse effects of industrial multiwalled carbon nanotubes on human pulmonary cells info:doi:10.1080/15287390802476991 info:eu-repo/semantics/altIdentifier/doi/10.1080/15287390802476991 info:eu-repo/semantics/altIdentifier/pmid/19034795 Tabet, Lyes Bussy, Cyrill Amara, Nadia Setyan, Ari Grodet, Alain Rossi Michel, J. Pairon, Jean-Claude Boczkowski, Jorge Lanone, Sophie info:eu-repo/semantics/article article 2009 Journal of Toxicology and Environmental Health. Part A, vol. 72, no. 2, pp. 60-73 info:eu-repo/semantics/altIdentifier/pissn/1528-7394 Nanotubes, Carbon; Asbestos, Amphibole; Asbestos, Serpentine; Soot; Oxidative Stress; Pulmonary Alveoli; Epithelial Cells; Apoptosis eng https://serval.unil.ch/resource/serval:BIB_4FDAF0543B78.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_4FDAF0543B789 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_4FDAF0543B789 info:eu-repo/semantics/submittedVersion info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_4FDB851850ED 2022-05-07T01:17:43Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_4FDB851850ED « Digital stylistic analyses in “PhraseoRom”: methodological and epistemological issues in a multidisciplinary project » Vidotto, Ilaria Jacquot, Clémence Gonon, Laetitia info:eu-repo/semantics/conferenceObject inproceedings Digital Stylistics in Romance Studies and Beyond eng oai:serval.unil.ch:BIB_4FDC597DC998 2022-05-07T01:17:43Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_4FDC597DC998 Distinct but overlapping T helper epitopes in the 37-58 region of SSX-2 info:doi:10.1016/j.clim.2004.08.014 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.clim.2004.08.014 info:eu-repo/semantics/altIdentifier/pmid/15596411 Ayyoub, M. Merlo, A. Hesdorffer, C. S. Speiser, D. Rimoldi, D. Cerottini, J. C. Ritter, G. Chen, Y. T. Old, L. J. Stevanovic, S. Valmori, D. info:eu-repo/semantics/article article 2005-01 Clinical Immunology, vol. 114, no. 1, pp. 70-8 info:eu-repo/semantics/altIdentifier/pissn/1521-6616 <![CDATA[Because of their specific expression in tumors of different histological types, the products of the SSX genes are important candidate targets for development of cancer vaccines. We have previously identified two immunodominant SSX-2-derived T cell epitopes recognized by HLA-A2-restricted CD8+ T cells (SSX-2 41-49) and HLA-DR11-restricted CD4+ T cells (SSX-2 45-59), respectively. In this study, we report the identification of an HLA-DR3-restricted epitope mapping to the 37-51 region of SSX-2, overlapping both previously identified epitopes. As about one fifth of individuals from several major ethnic groups express HLA-DR3, the identification of this epitope significantly increases the percent of patients that are expected to mount specific CD4+ T cell responses following vaccination with peptides in this region of SSX-2. Retrieval of multiple overlapping epitopes in a defined region of SSX-2 protein suggests the presence of a "hot spot" for T cell recognition that may prove sufficient for the induction of immune responses