Loop pipelining is widely adopted as a key optimization method in high-level synthesis (HLS). However, when complex memory dependencies appear in a loop, commercial HLS tools are still not able to maximize pipeline performance. In this paper, we leverage parametric polyhedral analysis to reason about memory dependence patterns that are uncertain (i.e., parameterised by an undetermined variable) and/or nonuniform (i.e., varying between loop iterations). We develop an automated source-to-source code transformation to split the loop into pieces, which are then synthesised by Vivado HLS as the hardware generation back-end. Our technique allows generated loops to run with a minimal interval, automatically inserting statically-determined parametr...