This thesis is concerned with the application of set-theoretical methods to problems in analysis, estimation and control of nonlinear systems. Set-theoretical concepts are often used in the formulation of various problems in science and engineering. One of the key enablers for the successful application of set-theoretical methods is the ability to enclose the image set of nonlinear multivariate systems, which is the focus of the main body of this thesis. Chapter 2 concentrates on bounding the image of factorable, vector-valued functions. To this aim, a framework is developed which enables the analysis of existing set-valued arithmetics---such as interval and polynomial model arithmetics---and the construction of new ones e.g. an elli...