Multiscale modelling and analysis of signalling processes in tissues with non-periodic distribution of cells

In this paper a microscopic model for a signalling process in the left ventricular wall of the heart, comprising a non-periodic brous microstructure, is considered. To derive the macroscopic equations the non-periodic microstructure is approximated by the corresponding locally-periodic microstructure. Then applying the methods of locally-periodic homogenization (the locallyperiodic (l-p) unfolding operator, locally-periodic two-scale (l-t-s) convergence on oscillating surfaces and l-p boundary unfolding operator) we obtain the macroscopic model for a signalling process in the heart tissue