6(17)-Epoxylathyrane diterpenes from Euphorbia sogdiana Popov with cytotoxic activity

Phytochem. anal. of Euphorbia sogdiana Popov, Euphorbiaceae, afforded the isolation of three new diterpenes based on the rare 6(17)-epoxylathyrane skeleton (1-3), along with a lathyrane (4), a myrsinane (5) and a tigliane (6) diterpenoids, previously isolated from Euphorbia aellenii. Their chem. structures were established through a combination of NMR spectroscopy and mass spectrometric methods. The epoxylathyranes 1-4 were tested to evaluate their cytotoxic activity against Jurkat T-leukemia and EJ-138 bladder cancer cells and their chem. analogy allowed to propose some structure activity relationships. [on SciFinder(R)