Aerobic Oxybromination of Phenols Catalyzed by Sodium Nitrite under Mild Conditions

Aerobic Oxybromination of Phenols Catalyzed by Sodium Nitrite under Mild ConditionsAn efficient catalytic system for oxybromination of phenols under mild conditions has been developed, which utilizes sodium nitrite as the catalyst, dioxygen or air as the terminal oxidant, aqueous hydrobromic acid or molecular bromine as the bromine resource. From both the atom-economic and environmental points of view, the developed protocol is expected to provide a valuable synthetic method for practical applications in laboratory or industry