Preparation of Poly(methyl methacrylate-co-1H,1H,7H- dodecafluoroheptyl methacrylate) Microspheres as Biomedical Materials

研究代表者共同研究者共同研究者共同研究者publisherMitsui, Syo[Abstract] Emulsion copolymerization of methyl methacrylate (MMA) and 1H,1H,7H- dodecafluoroheptyl methacrylate (DFHMA) yielded a series of copolymer microspheres, poly (MMA-co-DFH MA) with varying the molar ratio of the DFHMA moiety. Potassium peroxodisulfate(KPS) wasused as an initiator. The molar ratio in feed was varied as MMA : MFHMA =1.0 : 0.0, 0.95 : 0.05, 0.90 : 0.10, 0.85 :0.15 and 0.80 : 0.20. The resulting copolymer microspheres were characterized by scanning electron microscope (SEM). It was found that diameter ( d ) of poly(MMA-co-DFHMA)s increases from 90.0±104nm to 144.0±88nm with increasing the amount of DFHMA in feed, where d is determined by means of laser diffraction particle size analyzer. Poly(MMA-co-DFHMA)s were found to increase the contact angle of water (θ= 106°) and colza-oil (θ= 89°) compared with poly(methyl methacrylate)(PMMA). It was also confirmed from a cell culture test that the polymer films prepared from poly(MMA-co-DFHMA) showed an effective suppression of adhesiveness of HeLa cell