Complement dependent early immunological responses during ex vivo xenoperfusion of hCD46/HLA-E double transgenic pig forelimbs with human blood
- Bongoni, Anjan K
- Kiermeir, David
- Jenni, Hansjörg
- Bähr, Andrea
- Ayares, David
- Klymiuk, Nikolai
- Wolf, Eckhard
- Voegelin, Esther
- Constantinescu, Mihai A
- Seebach, Jorg Dieter
- Rieben, Robert
Publication date
January 2014
DOI Publisher
Wiley ISSN
0908-665X Citation count (estimate)
12Abstract
Besides α1,3-galactosyltransferase gene (GGTA1) knockout, several transgene combinations to prevent pig-to-human xenograft rejection are currently being investigated. In this study, the potential of combined overexpression of human CD46 and HLA-E to prevent complement- and NK-cell-mediated xenograft rejection was tested in an ex vivo pig-to-human xenoperfusion model
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