Multiple genetically modified GTKO/hCD46/HLA-E/hβ2-mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood
- Abicht, Jan-Michael
- Sfriso, Riccardo
- Reichart, Bruno
- Längin, Matthias
- Gahle, Katja
- Puga Yung, Gisella
- Seebach, Jorg Dieter
- Rieben, Robert
- Ayares, David
- Wolf, Eckhard
- Klymiuk, Nikolai
- Baehr, Andrea
- Kind, Alexander
- Mayr, Tanja
- Bauer, Andreas
DOIAbstract
In pig-to-human xenotransplantation, early cellular rejection reactions are mediated by natural killer cells (NK cells). Human NK cells are inhibited by HLA-E via CD94/NKG2A receptors. To protect porcine grafts against human NK cell responses, transgenic GTKO pigs expressing hCD46 and HLA-E have been generated. The aim of this study was to test the effect of this genetic modification on xenogeneic, and in particular human NK cell response, using an ex vivo perfusion model of pig hearts with human blood
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