Impaired blood rheology plays a role inthe chronic disorders associated with sickle cell- hemoglobin C disease: Blood viscosity in hemoglobin SC disease

Lemonne, Nathalie
Lamarre, Yann
Romana, Marc
Hardy-Dessources, Marie-Dominique
Lionnet, François
Waltz, Xavier
Tarer, Vanessa
Mougenel, Danielle
Tressières, Benoît
Lalanne-Mistrih, Marie-Laure
Etienne-Julan, Maryse
Connes, Philippe
Connes, Philippe

Publication date

March 2014

Publisher

Ferrata Storti Foundation (Haematologica)

Abstract

International audienceLionnet et al. recently reported a high prevalence of retinopathy (RET) and otologic disorders (OTD) in patients with sickle cell-hemoglobin C disease (SC), while a significant number of patients had renal diseases (mainly glomerulopathy; GLO) and osteonecrosis (OST). The pathophysiological processes of these complications in SC are not well defined, although blood hyperviscosity has been suspected, but never tested to the best of our knowledge, as responsible for several chronic complications in SC disease1,2. The aim of this study was to analyze the associations between hematological and hemorheological parameters and chronic complications in adult SC patients