Outcome of multimodal therapy in operated acromegalic patients, a study in 115 patients

International audienceIntroduction Given the new therapeutic options in acromeg-aly, it seemed important to evaluate the outcome of operated acromegalic patients today. Objective To analyse the characteristics and short-and long-term surgical outcome of patients who underwent transsphenoi-dal surgery for a growth hormone (GH)-secreting adenoma in our centre and to determine predictive factors of remission. Design and patients This retrospective 10-year study included 115 newly diagnosed acromegalic patients operated on at Timone University Hospital, Marseille, France, between 1997 and 2007. Measurements Initial and long-term outcomes were evaluated using stringent and current remission criteria, associating GH nadir after oral glucose tolerance test