Patterns of tissue-specific gene expression evolution between SARA and MANA mice in liver.

A). Percentage of each regulatory type in liver-specific, broadly expressed, and all genes. Genes of ambiguous regulatory type are not included. EDMAvMANA and BAT results can be found in S6–S8 Figs. B-C). Expected vs. observed number of significantly differentially expressed genes (DEGs) in liver-specific (B) and broadly expressed (C) genes. Dashed line indicates observed value. D). Effect size as measured as log2 fold change for liver-specific, broadly expressed, and all genes. E). Overlap of liver-specific DEGs between SARAvMANA and EDMAvMANA comparisons (FDR < 5%) and expected vs. observed overlap between SARAvMANA and EDMAvMANA liver-specific DEGs. Dashed line indicates observed value.