Transcriptomic profile of cluster 8.

(A) Volcano plot showing differentially expressed genes in Cluster 8 microglia compared to other hippocampal microglia. Statistically significant genes (up or down- regulated) are represented by red dots (LFC > 0.25 and p-val < 10e-32). (B) Gene set enrichment analysis of upregulated genes in cluster 8 showing select ontology related to neurogenesis. (C) Violin Plots showing comparison of expression profiles of key genes in Cluster 8 vs homeostatic clusters (13 and 14).