Weighted gene co-expression network analysis (WGCNA) of human brain transcriptomes.

<p>(A) Color map showing the relative sizes of the different modules in the WGCNA analysis. Colors correspond to arbitrary names given to each module. (B) Enrichment for genes up-regulated in Neurons (left), Astrocytes (center) and Oligodendrocytes (right). For each module, the relative risk (RR) for harboring cell-type specific genes is plotted. Insets show the distribution of the rank of enriched genes located in modules with the highest cell-type specific RR. The distribution is shown for the Salmon, Magenta and Blue module for genes enriched in neurons, astrocytes, and oligodendrocytes (respectively). (C) Top connected genes in the Magenta module. Nodes are ordered and sized according to their degree. (D) Top connected genes in the Yellow module, revealing two distinct groups of genes. One group (left circle) includes genes involved in protein translation, and the other (right circle) includes Microglia specific genes.