The study of programming with and reasoning about inductive datatypes such as lists and trees has benefited from the simple categorical principle of initial algebras. In initial algebra semantics, each inductive datatype is represented by an initial f-algebra for an appropriate functor f. The initial algebra principle then supports the straightforward derivation of definitional principles and proof principles for these datatypes. This technique has been expanded to a whole methodology of structured functional programming, often called origami programming. In this article we show how to extend initial algebra semantics from pure inductive datatypes to inductive datatypes interleaved with computational effects. Inductive datatypes interleaved...