Breast cancer is characterized by physical changes that occur in the tumor microenvironment throughout growth and metastasis of tumors. Extracellular matrix stiffness increases as tumors develop and spread, with stiffer environments thought to correlate with poorer disease prognosis. Changes in extracellular stiffness and other physical characteristics are sensed by integrins which integrate these extracellular cues to intracellular signaling, resulting in modulation of proliferation and invasion. However, the co-ordination of mechano-sensitive signaling with functional changes to groups of tumor cells within 3-dimensional environments remains poorly understood. Here we provide evidence that increasing the stiffness of collagen scaffolds re...
Increased tissue stiffness is a classic characteristic of solid tumors. One of the major contributin...
Increased tissue stiffness is a classic characteristic of solid tumors. One of the major contributin...
SummaryTumors are stiffer than normal tissue, and tumors have altered integrins. Because integrins a...
Breast cancer is characterized by physical changes that occur in the tumor microenvironment througho...
Breast cancer is characterized by physical changes that occur in the tumor microenvironment througho...
Breast cancer is characterized by physical changes that occur in the tumor microenvironment througho...
Breast cancer is characterized by physical changes that occur in the tumor microenvironment througho...
Breast cancer is characterized by physical changes that occur in the tumor microenvironment througho...
Breast cancer is characterized by physical changes that occur in the tumor microenvironment througho...
Breast cancer is the most common cancer of women worldwide and the second leading cause of cancer de...
The progression of mammary carcinoma involves a variety of cellular and environmental factors that f...
An increase in extracellular matrix stiffness enhances cancer cell migration and proliferation at th...
Predicting which benign and early stage breast lesions will transform is a major therapeutic challen...
Abstract Cervical cancer metastasis is an important cause of death in cervical cancer. Previous stud...
The mechanical properties of cancer cells and their microenvironment contribute to breast cancer pro...
Increased tissue stiffness is a classic characteristic of solid tumors. One of the major contributin...
Increased tissue stiffness is a classic characteristic of solid tumors. One of the major contributin...
SummaryTumors are stiffer than normal tissue, and tumors have altered integrins. Because integrins a...
Breast cancer is characterized by physical changes that occur in the tumor microenvironment througho...
Breast cancer is characterized by physical changes that occur in the tumor microenvironment througho...
Breast cancer is characterized by physical changes that occur in the tumor microenvironment througho...
Breast cancer is characterized by physical changes that occur in the tumor microenvironment througho...
Breast cancer is characterized by physical changes that occur in the tumor microenvironment througho...
Breast cancer is characterized by physical changes that occur in the tumor microenvironment througho...
Breast cancer is the most common cancer of women worldwide and the second leading cause of cancer de...
The progression of mammary carcinoma involves a variety of cellular and environmental factors that f...
An increase in extracellular matrix stiffness enhances cancer cell migration and proliferation at th...
Predicting which benign and early stage breast lesions will transform is a major therapeutic challen...
Abstract Cervical cancer metastasis is an important cause of death in cervical cancer. Previous stud...
The mechanical properties of cancer cells and their microenvironment contribute to breast cancer pro...
Increased tissue stiffness is a classic characteristic of solid tumors. One of the major contributin...
Increased tissue stiffness is a classic characteristic of solid tumors. One of the major contributin...
SummaryTumors are stiffer than normal tissue, and tumors have altered integrins. Because integrins a...