Temporal dynamics of ploidy variants in evolving populations.

(a) Aneuploidy frequency across the adaptive evolution experiment. The relative copy number of each chromosome, inferred from sequencing depth, is plotted for whole-population samples from the ALE experiment from approximately 50 generation intervals. The trajectories of aneuploidies that reached high frequencies are colored; all other chromosomes are black. The time points are the same as those sampled to assay ploidy states (S3B Fig). (b) Aneuploidies in whole-population samples are plotted against generations as in (a), but they are rescaled to frequency per haploid genome. The apparent frequency of haploids in each population from the same time points is plotted as green lines and was calculated from the flow cytometry data shown in S3B Fig. The data underlying this figure can be found in S1 Data. (TIF)