Comparison between severe and fatal states through genome-scale metabolic modelling.

Heatmaps showing the clustering of the different organs according to the activity of each reaction (left severe, right fatal state). Each column represents a reaction in the human metabolic network and its color accounts for the (normalized) activity of that specific reaction in the corresponding organ. In the heatmap on the left, three main clusters are labelled with a red, green and orange dot and the organs belonging to each cluster are labelled accordingly and this color code is maintained in the heatmap on the right. Organs changing clusters in the two heatmaps are connected with a line. (TIF)