A: We generated a synthetic population of 5 × 103 yeast metabolisms with relative gene (expression) dosages sampled from a normal distribution (Methods). For each individual, we calculate their growth rate with FBA. Such genetic variation induces a distribution of growth rates with mean and deviation 0.41 ± 0.03 h−1. The vertical dotted line shows here the growth rate (0.51 h−1) of a metabolism whose enzymes work at maximal efficiency. B: Scheme of central carbon metabolism showing population variation in each flux solution (coefficient of variation = σ/μ, where σ and μ is the population standard deviation and mean value, respectively, for each flux shown). C: We trained a PGS to predict growth rates from gene dosage data. The PGS explains ...
We studied the relationship between growth rate and genome-wide gene expression, cell cycle progress...
Most phenotypic traits are controlled by many genes, but a global picture of the genotype–phenotype ...
A: The range of flux potentially available in three reactions is represented by the white bars (from...
A: The statistical association of genetic and phenotypic variants in a training population defines a...
Using protein counts sampled from single cell proteomics distributions to constrain fluxes through a...
A: The precursors in metabolic reconstructions are metabolites that ultimately fuel the biomass reac...
Quantitative traits are measurable phenotypes that show continuous variation over a wide phenotypic ...
Engineering of metabolic pathways by genetic modification has been restricted largely to enzyme-enco...
No two living cells are exactly the same. Even cells from a clonal population with identical genomes...
© 2020 Juan F. Poyatos.Cells adjust their metabolism in response to mutations, but how this reprogra...
Background: Genome-wide sensitivity screens in yeast have been immensely popular fo...
The field of systems biology is often held back by difficulties in obtaining comprehensive, high-qua...
Genome‐scale metabolic models (GEMs) are widely used to calculate metabolic phenotypes. They rely on...
No two living cells are exactly the same. Even cells from a clonal population with identical genomes...
An iterative approach that integrates high-throughput measurements of yeast deletion mutants and flu...
We studied the relationship between growth rate and genome-wide gene expression, cell cycle progress...
Most phenotypic traits are controlled by many genes, but a global picture of the genotype–phenotype ...
A: The range of flux potentially available in three reactions is represented by the white bars (from...
A: The statistical association of genetic and phenotypic variants in a training population defines a...
Using protein counts sampled from single cell proteomics distributions to constrain fluxes through a...
A: The precursors in metabolic reconstructions are metabolites that ultimately fuel the biomass reac...
Quantitative traits are measurable phenotypes that show continuous variation over a wide phenotypic ...
Engineering of metabolic pathways by genetic modification has been restricted largely to enzyme-enco...
No two living cells are exactly the same. Even cells from a clonal population with identical genomes...
© 2020 Juan F. Poyatos.Cells adjust their metabolism in response to mutations, but how this reprogra...
Background: Genome-wide sensitivity screens in yeast have been immensely popular fo...
The field of systems biology is often held back by difficulties in obtaining comprehensive, high-qua...
Genome‐scale metabolic models (GEMs) are widely used to calculate metabolic phenotypes. They rely on...
No two living cells are exactly the same. Even cells from a clonal population with identical genomes...
An iterative approach that integrates high-throughput measurements of yeast deletion mutants and flu...
We studied the relationship between growth rate and genome-wide gene expression, cell cycle progress...
Most phenotypic traits are controlled by many genes, but a global picture of the genotype–phenotype ...
A: The range of flux potentially available in three reactions is represented by the white bars (from...