Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains
- Canelas, A.B.
- Harrison, N.
- Fazio, A.
- Zhang, J.
- Pitkanen, J.-P.
- van der Brink, J.
- Bakker, B.M.
- Bogner, L.
- Bouwman, J.
- Castrillo, J.I.
- Cankorur, A.
- Chumnanpuen, P.
- Daran-Lapujade, P.
- Dikicioglu, D.
- van Eunen, K.
- Ewald, J.C.
- Heijnen, J.J.
- Kirdar, B.
- Mattila, I.
- Mensonides, F.I.C.
- Niebel, A.
- Pentilla, M.
- Pronk, J.T.
- Reuss, M.
- Salusjarvi, L.
- Sauer, U.
- Sherman, D.
- Siemann-Herzberg, M.
- Westerhoff, H.V.
- de Winde, J.H.
- Petranovi, D.
- Oliver, S.G.
- Workman, T.
- Zamboni, N.
- Nielsen, J.
DOIAbstract
The field of systems biology is often held back by difficulties in obtaining comprehensive, high-quality, quantitative data sets. In this paper, we undertook an interlaboratory effort to generate such a data set for a very large number of cellular components in the yeast Saccharomyces cerevisiae, a widely used model organism that is also used in the production of fuels, chemicals, food ingredients and pharmaceuticals. With the current focus on biofuels and sustainability, there is much interest in harnessing this species as a general cell factory. In this study, we characterized two yeast strains, under two standard growth conditions. We ensured the high quality of the experimental data by evaluating a wide range of sampling and analytical ...
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