In this thesis we study homological stability properties of different families of spaces using the technique of cellular *Ek*-algebras. Firstly, we will consider spin mapping class groups of surfaces, and their algebraic analogue —quadratic symplectic groups— using cellular *E2*-algebras. We will obtain improvements in their stability results, which for the spin mapping class groups we will show to be optimal away from the prime 2. We will also prove that in both cases the $\mathbb{F}$2-homology satisfies secondary homological stability. Finally, we will give full descriptions of the first homology groups of the spin mapping class groups and of the quadratic symplectic groups. Secondly, we will study the classifying spaces of the diffeomorp...