The efficient delivery of therapeutic molecules to the cartilage of joints is major obstacle in developing useful therapeutic interventions; hence, a targeted drug delivery system for this tissue is critical. We have overcome the challenge by developing a system that employs electrostatic attraction between the negatively charged constituents of cartilage and a positively charged polymer, poly-beta amino esters (PBAEs). We have demonstrated cartilage uptake of dexamethasone (DEX) covalently bound to the PBAE was doubled and retention in tissues prolonged compared to the equivalent dose of the commercial drug formulation. Moreover, no adverse effects on chondrocytes were found. Our data also show that PBAEs can bind not only healthy cartilag...
Purpose: The purpose of this study is to develop the nanoparticles that i) can be injected intra-art...
Osteoarthritis (OA) is one of the considerable chronic health conditions worldwide. In the UK, 8.75 ...
Osteoarthritis (OA) is one of the considerable chronic health conditions worldwide. In the UK, 8.75 ...
The efficient delivery of therapeutic molecules to the cartilage of joints is major obstacle in deve...
The efficient delivery of therapeutic molecules to the cartilage of joints is major obstacle in deve...
Drug localisation is still one of the main challenges in treating pathologies affecting cartilage; p...
Drug localisation is still one of the main challenges in treating pathologies affecting cartilage; p...
Drug localisation is still one of the main challenges in treating pathologies affecting cartilage; p...
Delivering drugs directly into cartilage is still the major challenge in the management and treatmen...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2019"DO...
Despite the large prevalence of diseases affecting cartilage (e.g. knee osteoarthritis affecting 16%...
Despite the large prevalence of diseases affecting cartilage (e.g. knee osteoarthritis affecting 16%...
Despite the large prevalence of diseases affecting cartilage (e.g. knee osteoarthritis affecting 16%...
Despite the large prevalence of diseases affecting cartilage (e.g. knee osteoarthritis affecting 16%...
Despite the large prevalence of diseases affecting cartilage (e.g. knee osteoarthritis affecting 16%...
Purpose: The purpose of this study is to develop the nanoparticles that i) can be injected intra-art...
Osteoarthritis (OA) is one of the considerable chronic health conditions worldwide. In the UK, 8.75 ...
Osteoarthritis (OA) is one of the considerable chronic health conditions worldwide. In the UK, 8.75 ...
The efficient delivery of therapeutic molecules to the cartilage of joints is major obstacle in deve...
The efficient delivery of therapeutic molecules to the cartilage of joints is major obstacle in deve...
Drug localisation is still one of the main challenges in treating pathologies affecting cartilage; p...
Drug localisation is still one of the main challenges in treating pathologies affecting cartilage; p...
Drug localisation is still one of the main challenges in treating pathologies affecting cartilage; p...
Delivering drugs directly into cartilage is still the major challenge in the management and treatmen...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2019"DO...
Despite the large prevalence of diseases affecting cartilage (e.g. knee osteoarthritis affecting 16%...
Despite the large prevalence of diseases affecting cartilage (e.g. knee osteoarthritis affecting 16%...
Despite the large prevalence of diseases affecting cartilage (e.g. knee osteoarthritis affecting 16%...
Despite the large prevalence of diseases affecting cartilage (e.g. knee osteoarthritis affecting 16%...
Despite the large prevalence of diseases affecting cartilage (e.g. knee osteoarthritis affecting 16%...
Purpose: The purpose of this study is to develop the nanoparticles that i) can be injected intra-art...
Osteoarthritis (OA) is one of the considerable chronic health conditions worldwide. In the UK, 8.75 ...
Osteoarthritis (OA) is one of the considerable chronic health conditions worldwide. In the UK, 8.75 ...