Supplementary Fig. 7 from Spatial Profiling of Circular RNAs in Cancer Reveals High Expression in Muscle and Stromal Cells

Single molecule in situ hybridization for circITGA7 and circHIPK3 in colon adenocarcinoma and adjacent normal tissues. A, B. Brightfield and fluorescent microscopy images at 200X magnification. A strong signal from circITGA7 can be observed in muscle cells, whereas the epithelium, tumor stroma, and cancer cells were negative (A). A signal from circHIPK3 can be observed in the epithelium, tumor stroma, muscle, and cancer cells (B).