Add to ORKGThe systemic inflammatory response and progression to secondary organ dysfunction are manifestations of the host\u27s responses to injury. This article outlines the clinical manifestations of this injury-response cascade. The potential roles of cytokines, eicosanoids, platelet-activating factor, nitric oxide, oxygen-free radicals, and the leukocyte-endothelial interaction are explored in some detail. A goal-directed therapy of source control, resuscitation, and metabolic support is reviewed, and new therapies with monoclonal antibodies and immunomodulated nutrition are described. These new therapies hold great potential for finally improving the outcome of this fatal syndrome
When a traumatic injury exceeds the body’s internal tolerances, the innate immune and inflammatory sy...
In 1992, the concept systemic inflammatory response syndrome (SIRS) was advocated. This term indicat...
Sepsis, the systemic inflammatory response to an infection, is an increasingly common condi-tion. It...
The systemic inflammatory response and progression to secondary organ dysfunction are manifestations...
Trauma results in tissue damage. Thereby, the extracellular matrix is disrupted and cells break apar...
Sepsis and SIRS is the outward manifestation of a generalized uncontrolled inflammatory response, wh...
Sepsis and SIRS is the outward manifestation of a generalized uncontrolled inflammatory response, wh...
Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction. Knowledge ...
Improvements in the control of haemorrhage after trauma have resulted in the survival of many people...
Background/Aims: Sepsis and multiple organ failure are complex processes that result from dysregulat...
Improvements in the control of haemorrhage after trauma have resulted in the survival of many people...
A disproportional innate immune response underlies the pathogenesis of organ failure and sepsis as s...
Patients with critical illness-induced multiple organ failure suffer from a very high morbidity and ...
Abstract Immune dysfunction can provoke (multiple) organ failure in severely injured patients. This ...
peer reviewedDuring sepsis, the systemic inflammatory response is characterized by the release of nu...
When a traumatic injury exceeds the body’s internal tolerances, the innate immune and inflammatory sy...
In 1992, the concept systemic inflammatory response syndrome (SIRS) was advocated. This term indicat...
Sepsis, the systemic inflammatory response to an infection, is an increasingly common condi-tion. It...
The systemic inflammatory response and progression to secondary organ dysfunction are manifestations...
Trauma results in tissue damage. Thereby, the extracellular matrix is disrupted and cells break apar...
Sepsis and SIRS is the outward manifestation of a generalized uncontrolled inflammatory response, wh...
Sepsis and SIRS is the outward manifestation of a generalized uncontrolled inflammatory response, wh...
Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction. Knowledge ...
Improvements in the control of haemorrhage after trauma have resulted in the survival of many people...
Background/Aims: Sepsis and multiple organ failure are complex processes that result from dysregulat...
Improvements in the control of haemorrhage after trauma have resulted in the survival of many people...
A disproportional innate immune response underlies the pathogenesis of organ failure and sepsis as s...
Patients with critical illness-induced multiple organ failure suffer from a very high morbidity and ...
Abstract Immune dysfunction can provoke (multiple) organ failure in severely injured patients. This ...
peer reviewedDuring sepsis, the systemic inflammatory response is characterized by the release of nu...
When a traumatic injury exceeds the body’s internal tolerances, the innate immune and inflammatory sy...
In 1992, the concept systemic inflammatory response syndrome (SIRS) was advocated. This term indicat...
Sepsis, the systemic inflammatory response to an infection, is an increasingly common condi-tion. It...