The objective: to substantiate the methodological approaches to the target management (TM) of a health care institution (HCI) in the context of the implementation of public-private partnership (PPP). Materials and methods. General scientific methods of analysis, synthesis, interpretation of scientific data, as well as systemic and structural-functional approaches were used in the work. Results. The article developed methodological approaches to HCI’s TM in the context of PPP, the features of using the system of target indicators are presented, a scheme for improving the production efficiency of medical activities, an informative map of indicators and methods for monitoring, calculating and analyzing individual targets is given. Conclusions....