Haplotype analysis fails to identify a gene from the <i>Ifnb1</i> induction pathway associated with uncontrolled viral replication.

(A) Identification of CC strains which carry the same ancestral haplotype as CC071 at the genes involved in the pathway leading to Ifnb1 expression. Colored boxes indicate matched haplotypes between CC071 and other CC strains. Letters and colors designate the eight CC founder strains. A: A/J (yellow); B: C57BL/6J; C: 129S1/SvImJ (pink); D: NOD/ShiLtJ; E: NZO/HILtJ (light blue); F: CAST/EiJ (green); G: PWK/PhJ (red); H: WSB/EiJ (purple). Doubled letters (eg AA) indicate homozygous genotypes. Heterozygous genotypes are indicated by the two corresponding letters (eg AD). (B) Kinetics of viral titer in MEFs from CC071 and the 8 CC strains shown in (A). Experimental conditions were as in Fig 1A n: number of technical replicates for each strain. Data are mean +/- sem from the technical replicates. Letters show statistical significance between CC071 and other strains. (ANOVA followed by Tukey HSD, a: p < 0.05, b: p < 0.01, c: p < 0.001).