Mucosal surfaces serve as the primary entry points for pathogens such as SARS- CoV-2 coronavirus or HIV in the human body. Mucosal vaccination plays a crucial role to successfully induce long-lasting systemic and local immune responses to confer sterilizing immunity. However, antigen formulations and delivery methods must be properly selected since they are decisive for the quality and the magnitude of the elicited immune responses in mucosa. We investigated the significance of using particulate antigen forms for mucosal vaccination by comparing VLP- or protein- based vaccines in a mouse model. Based on a mucosal prime-boost immunization protocol combining (i) HIV- pseudotyped recombinant VLPs (HIV-VLPs) and (ii) plasmid DNA encoding HIV- V...
The induction of a strong mucosal immune response is essential to building successful HIV vaccines. ...
The gut mucosa is an important portal for HIV-1 transmission and infection. Therefore, a vaccine whi...
While current COVID-19 vaccines provide certain protection, more effective vaccination strategies ar...
Mucosal surfaces serve as the primary entry points for pathogens such as SARS- CoV-2 coronavirus or ...
<div><p>Increasing evidence suggests that mucosally targeted vaccines will enhance local humoral and...
Many viral structural proteins are capable of spontaneously self-assembling into structures that res...
The immune response to HIV-1 virus-like particles (VLPs), presenting a clade A Ugandan gp120, has be...
Increasing evidence suggests that mucosally targeted vaccines will enhance local humoral and cellula...
An effective HIV vaccine will likely require induction of both mucosal and systemic cellular and hum...
An effective HIV vaccine will likely require induction of both mucosal and systemic cellular and hum...
It has been shown previously that recombinant virus-like particles (VLPs) of papillomavirus can indu...
AbstractIt has been shown previously that recombinant virus-like particles (VLPs) of papillomavirus ...
A variety of DNA vaccine prime and recombinant viral boost immunization strategies have been develop...
<div><p>Induction of local antiviral immune responses at the mucosal portal surfaces where HIV-1 and...
ABSTRACT Previously, a modified HIV Env protein with a heterologous membrane anchor was found to be ...
The induction of a strong mucosal immune response is essential to building successful HIV vaccines. ...
The gut mucosa is an important portal for HIV-1 transmission and infection. Therefore, a vaccine whi...
While current COVID-19 vaccines provide certain protection, more effective vaccination strategies ar...
Mucosal surfaces serve as the primary entry points for pathogens such as SARS- CoV-2 coronavirus or ...
<div><p>Increasing evidence suggests that mucosally targeted vaccines will enhance local humoral and...
Many viral structural proteins are capable of spontaneously self-assembling into structures that res...
The immune response to HIV-1 virus-like particles (VLPs), presenting a clade A Ugandan gp120, has be...
Increasing evidence suggests that mucosally targeted vaccines will enhance local humoral and cellula...
An effective HIV vaccine will likely require induction of both mucosal and systemic cellular and hum...
An effective HIV vaccine will likely require induction of both mucosal and systemic cellular and hum...
It has been shown previously that recombinant virus-like particles (VLPs) of papillomavirus can indu...
AbstractIt has been shown previously that recombinant virus-like particles (VLPs) of papillomavirus ...
A variety of DNA vaccine prime and recombinant viral boost immunization strategies have been develop...
<div><p>Induction of local antiviral immune responses at the mucosal portal surfaces where HIV-1 and...
ABSTRACT Previously, a modified HIV Env protein with a heterologous membrane anchor was found to be ...
The induction of a strong mucosal immune response is essential to building successful HIV vaccines. ...
The gut mucosa is an important portal for HIV-1 transmission and infection. Therefore, a vaccine whi...
While current COVID-19 vaccines provide certain protection, more effective vaccination strategies ar...