The role of the gut microbiota and the use of new therapies in Irritable Bowel Syndrome

DĄBROWSKI, Jan, GĄBKA, Ilona, DALMATA, Weronika, GENDEK, Karolina, KOZŁOWSKA, Anna, KORZENIOWSKA, Anna and ZAŁĘSKA, Natalia. The role of the gut microbiota and the use of new therapies in Irritable Bowel Syndrome. Journal of Education, Health and Sport. 2023;17(1):216-225. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.17.01.018 https://apcz.umk.pl/JEHS/article/view/45724 https://zenodo.org/record/8330337 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2023; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 14.08.2023. Revised: 24.08.2023. Accepted: 06.09.2023. Published: 14.09.2023. The role of the gut microbiota and the use of new therapies in Irritable Bowel Syndrome Rola mikrobioty jelitowej oraz stosowania nowych terapii w Zespole Jelita Drażliwego Jan Dąbrowski Medical University of Lublin Al. Racławickie 1, 20-059 Lublin, Poland ORCID: 0000-0002-4930-7412 jasiek.dabrowsky@gmail.com Ilona Gąbka Medical University of Lublin Al. Racławickie 1, 20-059 Lublin, Poland ORCID: 0000-0003-4202-8338 ilona0002@gmail.com Weronika Dalmata Medical University of Lublin Al. Racławickie 1, 20-059 Lublin, Poland ORCID: 0000-0003-0529-5998 wercia_2205@wp.pl Karolina Gendek Medical University of Lublin Al. Racławickie 1, 20-059 Lublin, Poland ORCID: 0000-0003-2348-4936 karolinagendek7@gmail.com Anna Kozłowska Independent Public Clinical Hospital No. 4 in Lublin, ul. Jaczewskiego 8, 20-954 Lublin, Poland ORCID: 0000-0001-6719-9331 kozlowska1963@wp.pl Anna Korzeniowska Independent Public Clinical Hospital No. 4 in Lublin, ul. Jaczewskiego 8, 20-954 Lublin, Poland ORCID: 0000-0001-5553-1501 akorz9607@gmail.com Natalia Załęska Medical University of Lublin Al. Racławickie 1, 20-059 Lublin, Poland ORCID: 0009-0003-4406-927X zaleska.natalia@gmail.com ABSTRACT Introduction: Irritable bowel syndrome is a functional disorder of the gastrointestinal tract with a multifactorial nature of the disease. IBS affects 11% of the population, with the gut microbiota playing an important role in the pathophysiology. Purpose: The aim of this article is to present the course of irritable bowel syndrome, the role of the gut microbiota in pathophysiology, and new therapeutic approaches, including probiotics, based on the current state of knowledge. Conclusions: IBS is a syndrome whose exact pathophysiology is not fully understood. The state of the gut microbiota has a huge impact on the course of the disease, but also on the functioning of the whole body. New therapies currently in use, i.e. probiotics, are showing promising results, but more research is needed to find the golden mean to treat the disease. Methods: Data for the article were retrieved using PubMed setting the time descriptors to 2013-2023. Keywords: irritable bowel syndrome, gut microflora, probiotic, prebiotic, fmt, gut-brains axis, dysbiosi