Neoangiogenesis in the dynamics of testicular seminoma progression

Potapov Serhii M., Halata Daria I., Pliten Oksana M., Horhol Nataliia I. Neoangiogenesis in the dynamics of testicular seminoma progression. Journal of Education, Health and Sport. 2019;9(11):137-147. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3548910 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/27946 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 06.11.2019. Revised: 14.11.2019. Accepted: 20.11.2019. NEOANGIOGENESIS IN THE DYNAMICS OF TESTICULAR SEMINOMA PROGRESSION Serhii M. Potapov, Daria I. Halata, Oksana M. Pliten, Nataliia I. Horhol Department of Pathological Anatomy, Kharkiv National Medical University, Kharkiv, 61022, Ukraine Abstract Testicular germ cell tumors (TGCT) is a group of neoplasms which develop from the germ cell epithelium and account 94-96% of all testicular tumors. Seminoma is the most common testicular germ cell neoplasm and accounts for about 50% of all TGCT. There is an increasing evidence that metastatic disease in both early and late stages depends on the degree of tumor vascularization. But despite the large number of publications on this subject, the ways of new vessels formation in invasive neoplasms and effect of the intratumoral vessels density on overall and relapse-free survival rate remain unclear. The performed investigation of neoangiogenesis in the dynamics of testicular seminoma progression revealed: significant increasing of relative area of CD31 and CD34 expression as well as vascular density during transition from the initial to the late stages of tumor progression; formation of intratumoral vessels in the seminoma occurs by angiogenesis and vasculogenesis with participation of progenitor endothelial cells; seminoma is characterized by vasculogenic mimicry in the form of channels formation that do not have endothelial lining. Key words: testicular germ cell tumors; seminoma; angiogenesis; immunohistochemical investigation