Neoangiogenesis - forming an effective network of blood vessels as a critical determinant of tumor development

Wróbel Grzegorz, Spałek Jakub, Zieliński Paweł. Neoangiogenesis - forming an effective network of blood vessels as a critical determinant of tumor development. Journal of Education, Health and Sport. 2017;7(12):339-348. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1139224 http://ojs.ukw.edu.pl/index.php/johs/article/view/5196 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.12.2017. Revised: 15.12.2017. Accepted: 28.12.2017. Neoangiogenesis - forming an effective network of blood vessels as a critical determinant of tumor development Grzegorz Wróbel1, Jakub Spałek1, Paweł Zieliński1 1 Department of Anatomy, Faculty of Medicine and Health Sciences, Jan Kochanowski University, Kielce, Poland Correspondence: Department of Anatomy, Faculty of Medicine and Health Sciences, Jan Kochanowski University, Al. IX Wieków Kielc 19A, 25-317 Kielce, Poland. Tel: 413496965. E-mail: grzegorz.wrobel@ujk.edu.pl Abstract The development of a tumor in the early stages of growth is associated with the delivery of nutrients and oxygen to the tumor cells by diffusion from the surrounding healthy tissue, while in the later stages, when the tumor size is so large that it begins to lack oxygen and nutrients, comes to neoangiogenesis - the formation of blood vessels in the area of the affected tissue. Tumor vessels are leaky, winding and have a lot of bottlenecks and dead-ends. Abnormalities of blood vessels anatomy determine the deceleration rate and residual blood flow. Tumor vascularization affects its local growth, and in the case of tumors with the potential to distant metastases, the increase vascularity of tumor by increasing the density of the blood vessel network is directly proportional to the risk of distant metastasis. The aim of the study was to summary the role of the formation of tumor blood vessels in the context of the development of tumors. Keywords: tumour vascularization, neoangiogenesi